|1840 - 1846||Bishop Francisco Garcia Diego y Moreno|
|1850 - 1853||Bishop Joseph S. Alemany|
|1854 - 1878||Bishop Thaddeus Amat|
|1878 - 1896||Bishop Francis Mora|
|1896 - 1903||Bishop George T. Montgomery|
|1903 - 1915||Bishop Thomas J. Conaty|
|1917 - 1947||Archbishop John J. Cantwell|
|1948 - 1970||Cardinal James Francis McIntyre|
|1970 - 1985||Cardinal Timothy Manning|
|1985 - 2011||Cardinal Roger M. Mahony|
|2011 - Present||Archbishop José Horacio Gómez|
Bishop Amat moved the seat of the Monterey-Los Angeles Diocese to Los Angeles in 1859. It was under his oversight that, in 1876, St. Vibiana Cathedral was built.
Archbishop John J. Cantwell served as head of the Los Angeles Archdiocese for 30 years, longer than any in his succession. The Los Angeles diocese was elevated to an Archdiocese and Bishop Cantwell to Archbishop in 1936.
Archbishop J. Francis McIntyre was appointed by Pope Pius XII in 1952 to become the first Cardinal in the western United States.
Cardinal Roger M. Mahony was the first head of the Los Angeles Archdiocese to have been born in Los Angeles.
Archbishop Gómez is the first Hispanic to serve as Archbishop of Los Angeles.