| Year | Winner | Category | Institution* |
|---|---|---|---|
| 1923 | Robert A. Millikan | Physics | CalTech |
| 1933 | Thomas Hunt Morgan | Physiology or Medicine | CalTech |
| 1936 | Carl D. Anderson | Physics† | CalTech |
| 1950 | Ralph Bunche | Peace | UCLA |
| 1951 | Edwin Mattison McMillan | Chemistry† | CalTech |
| Glenn T. Seaborg | Chemistry† | UCLA | |
| 1954 | Linus Pauling | Chemistry | CalTech |
| 1956 | William Shockley | Physics† | CalTech |
| 1958 | George Wells Beadle | Physiology or Medicine† | CalTech |
| 1960 | Donald A. Glaser | Physics | CalTech |
| Willard Libby | Chemistry | UCLA | |
| 1961 | Rudolf Mössbauer | Physics | CalTech |
| 1962 | Linus Pauling | Peace | CalTech |
| 1964 | Charles H. Townes | Physics† | CalTech |
| 1965 | Richard P. Feynman | Physics† | CalTech |
| Julian Schwinger | Physics† | UCLA | |
| 1969 | Murray Gell-Mann | Physics | CalTech, USC |
| Max Delbrück | Physiology or Medicine† | CalTech | |
| 1975 | Leo James Rainwater | Physics† | CalTech |
| David Baltimore | Physiology or Medicine† | CalTech | |
| Renato Dulbecco | Physiology or Medicine† | CalTech | |
| Howard M. Temin | Physiology or Medicine† | CalTech | |
| 1976 | William Lipscomb | Chemistry | CalTech |
| 1978 | Robert Woodrow Wilson | Physics | CalTech |
| Werner Arber | Physiology or Medicine† | USC | |
| 1981 | Roger W. Sperry | Physiology or Medicine† | CalTech |
| 1982 | Kenneth G. Wilson | Physics | CalTech |
| 1983 | William A. Fowler | Physics† | CalTech |
| 1984 | Bruce Merrifield | Chemistry | UCLA |
| 1987 | Donald Cram | Chemistry† | UCLA |
| 1990 | William F. Sharpe | Economics† | UCLA |
| 1992 | Rudolph A. Marcus | Chemistry | CalTech |
| 1993 | Phillip A. Sharp | Physiology or Medicine† | CalTech |
| 1994 | George Andrew Olah | Chemistry | USC |
| 1995 | Edward B. Lewis | Physiology or Medicine† | CalTech |
| 1996 | Douglas D. Osheroff | Physics† | CalTech |
| 1997 | Paul D. Boyer | Chemistry† | UCLA |
| Robert C. Merton | Economics† | CalTech | |
| 1998 | Louis Ignarro | Physiology or Medicine† | UCLA |
| 1999 | Ahmed Zewail | Chemistry | CalTech |
| 2000 | Daniel McFadden | Economics† | USC |
| 2001 | Leland H. Hartwell | Physiology or Medicine† | CalTech |
| 2002 | Vernon L. Smith | Economics | CalTech |
| 2004 | H. David Politzer | Physics† | CalTech |
| 2005 | Robert H. Grubbs | Chemistry† | CalTech |
| 2009 | Elinor Ostrom | Economics† | UCLA |
| 2010 | Richard Heck | Chemistry† | UCLA |
| Robert G. Edwards | Physiology or Medicine | CalTech | |
| 2012 | Lloyd Shapley | Economics† | UCLA |
| Sir John B. Gurdon | Physiology or Medicine† | CalTech | |
| 2013 | Arieh Warshel | Chemistry† | USC |
| Martin Karplus | Chemistry† | CalTech | |
| Randy Schekman | Physiology or Medicine† | UCLA | |
| 2014 | Eric Betzig | Chemistry† | CalTech |
| 2015 | Arthur B. McDonald | Physics† | CalTech |
| 2016 | Fraser Stoddart | Chemistry† | UCLA |
| 2017 | Barry C. Barish | Physics† | CalTech |
| Kip S. Thorne | Physics† | CalTech | |
| Jeffrey C. Hall | Physiology or Medicine† | CalTech | |
| Michael Rosbash | Physiology or Medicine† | CalTech | |
| 2018 | Frances Arnold | Chemistry | CalTech |
| 2020 | Andrea M. Ghez | Physics† | CalTech |
| Jennifer Doudna | Chemistry† | Pomona College | |
| Charles M. Rice | Physiology or Medicine† | CalTech | |
| 2021 | Ardem Patapoutian | Physiology or Medicine† | UCLA |
| 2022 | John Clauser | Physics† | CalTech |
| 2024 | John Hopfield | Physics† | CalTech |
| 2024 | James Robinson | Economics† | USC |
| 2025 | John Martinis | Physics† | Qolab, Los Angeles |
| Fred Ramsdell | Physiology or Medicine† | UCLA | |
| Richard Robson | Chemistry† | CalTech | |
| Omar Yaghi | Chemistry† | UCLA |
* Winner had been a student/graduate/professor/researcher at this Los Angeles County institution.
† Co-winner of the prize
Source: Nobel Prizes
