| Year | Winner | Institution | Category |
|---|---|---|---|
| 1923 | Robert A. Millikan | Cal Tech | Physics |
| 1933 | Thomas Hunt Morgan | Cal Tech | Physiology or Medicine |
| 1936 | Carl D. Anderson | Cal Tech | Physics† |
| 1950 | Ralph Bunche | UCLA* | Peace |
| 1951 | Edwin Mattison McMillan | Cal Tech* | Chemistry† |
| 1951 | Glenn T. Seaborg | UCLA* | Chemistry† |
| 1954 | Linus Pauling | Cal Tech | Chemistry |
| 1956 | William Shockley | Cal Tech* | Physics† |
| 1958 | George Wells Beadle | Cal Tech | Physiology or Medicine |
| 1960 | Donald A. Glaser | Cal Tech* | Physics |
| 1960 | Willard Libby | UCLA | Chemistry |
| 1961 | Rudolf Mössbauer | Cal Tech | Physics |
| 1962 | Linus Pauling | Cal Tech | Peace |
| 1964 | Charles H. Townes | Cal Tech* | Physics† |
| 1965 | Richard P. Feynman | Cal Tech | Physics† |
| 1969 | Max Delbrück | Cal Tech | Physiology or Medicine† |
| 1969 | Murray Gell-Mann | Cal Tech | Physics |
| 1975 | Leo James Rainwater | Cal Tech* | Physics† |
| 1976 | William Lipscomb | Cal Tech* | Chemistry |
| 1978 | Robert Woodrow Wilson | Cal Tech* | Physics |
| 1981 | Roger W. Sperry | Cal Tech | Physiology or Medicine† |
| 1982 | Kenneth G. Wilson | Cal Tech* | Physics |
| 1983 | William A. Fowler | Cal Tech | Physics† |
| 1984 | Bruce Merrifield | UCLA* | Chemistry |
| 1987 | Donald Cram | UCLA | Chemistry† |
| 1990 | William F. Sharpe | UCLA* | Economics† |
| 1992 | Rudolph A. Marcus | Cal Tech | Chemistry |
| 1994 | George Andrew Olah | USC | Chemistry |
| 1995 | Edward B. Lewis | Cal Tech | Physiology or Medicine† |
| 1996 | Douglas D. Osheroff | Cal Tech* | Physics† |
| 1997 | Paul D. Boyer | UCLA | Chemistry† |
| 1997 | Robert C. Merton | Cal Tech* | Economics† |
| 1998 | Louis Ignarro | UCLA | Physiology or Medicine† |
| 1999 | Ahmed Zewail | Cal Tech | Chemistry |
| 2001 | Leland H. Hartwell | Cal Tech* | Physiology or Medicine† |
| 2002 | Vernon L. Smith | Cal Tech* | Economics |
| 2004 | H. David Politzer | Cal Tech | Physics† |
| 2005 | Robert H. Grubbs | Cal Tech | Chemistry† |
| 2009 | Elinor Ostrom | UCLA* | Economics† |
| 2010 | Richard Heck | UCLA* | Chemistry† |
| 2012 | Lloyd Shapley | UCLA | Economics† |
| 2013 | Arieh Warshel | USC | Chemistry† |
| 2013 | Martin Karplus | Cal Tech* | Chemistry† |
| 2013 | Randy Schekman | UCLA* | Physiology or Medicine† |
| 2014 | Eric Betzig | Cal Tech* | Chemistry† |
| 2015 | Arthur B. McDonald | Cal Tech* | Physics† |
| 2016 | Fraser Stoddart | UCLA* | Chemistry† |
| 2017 | Barry C. Barish | CalTech | Physics† |
| 2017 | Michael Rosbash | CalTech* | Physiology or Medicine† |
| 2018 | Frances Arnold | CalTech | Chemistry |
| 2020 | Charles M. Rice | CalTech* | Physiology or Medicine† |
| 2020 | Andrea M. Ghez | CalTech*; UCLA | Physics† |
| 2020 | Jennifer Doudna | Pomona College* | Chemistry† |
| 2021 | Ardem Patapoutian | UCLA*, CalTech* | Physiology or Medicine† |
* Winner had been a student/graduate/professor of this institution, but was not awarded the prize while there.
† Co-winner of the prize
Source: Nobel Prizes
