| Year | Winner | Institution | Category |
|---|---|---|---|
| 1923 | Robert A. Millikan | CalTech | Physics |
| 1933 | Thomas Hunt Morgan | CalTech | Physiology or Medicine |
| 1936 | Carl D. Anderson | CalTech | Physics† |
| 1950 | Ralph Bunche | UCLA* | Peace |
| 1951 | Edwin Mattison McMillan | CalTech* | Chemistry† |
| Glenn T. Seaborg | UCLA* | Chemistry† | |
| 1954 | Linus Pauling | CalTech | Chemistry |
| 1956 | William Shockley | CalTech* | Physics† |
| 1958 | George Wells Beadle | CalTech | Physiology or Medicine |
| 1960 | Donald A. Glaser | CalTech* | Physics |
| Willard Libby | UCLA | Chemistry | |
| 1961 | Rudolf Mössbauer | CalTech | Physics |
| 1962 | Linus Pauling | CalTech | Peace |
| 1964 | Charles H. Townes | CalTech* | Physics† |
| 1965 | Richard P. Feynman | CalTech | Physics† |
| 1969 | Murray Gell-Mann | CalTech | Physics |
| Max Delbrück | CalTech | Physiology or Medicine† | |
| 1975 | Leo James Rainwater | CalTech* | Physics† |
| 1976 | William Lipscomb | CalTech* | Chemistry |
| 1978 | Robert Woodrow Wilson | CalTech* | Physics |
| 1981 | Roger W. Sperry | CalTech | Physiology or Medicine† |
| 1982 | Kenneth G. Wilson | CalTech* | Physics |
| 1983 | William A. Fowler | CalTech | Physics† |
| 1984 | Bruce Merrifield | UCLA* | Chemistry |
| 1987 | Donald Cram | UCLA | Chemistry† |
| 1990 | William F. Sharpe | UCLA* | Economics† |
| 1992 | Rudolph A. Marcus | CalTech | Chemistry |
| 1994 | George Andrew Olah | USC | Chemistry |
| 1995 | Edward B. Lewis | CalTech | Physiology or Medicine† |
| 1996 | Douglas D. Osheroff | CalTech* | Physics† |
| 1997 | Paul D. Boyer | UCLA | Chemistry† |
| Robert C. Merton | CalTech* | Economics† | |
| 1998 | Louis Ignarro | UCLA | Physiology or Medicine† |
| 1999 | Ahmed Zewail | CalTech | Chemistry |
| 2001 | Leland H. Hartwell | CalTech* | Physiology or Medicine† |
| 2002 | Vernon L. Smith | CalTech* | Economics |
| 2004 | H. David Politzer | CalTech | Physics† |
| 2005 | Robert H. Grubbs | CalTech | Chemistry† |
| 2009 | Elinor Ostrom | UCLA* | Economics† |
| 2010 | Richard Heck | UCLA* | Chemistry† |
| 2012 | Lloyd Shapley | UCLA | Economics† |
| 2013 | Arieh Warshel | USC | Chemistry† |
| Martin Karplus | CalTech* | Chemistry† | |
| Randy Schekman | UCLA* | Physiology or Medicine† | |
| 2014 | Eric Betzig | CalTech* | Chemistry† |
| 2015 | Arthur B. McDonald | CalTech* | Physics† |
| 2016 | Fraser Stoddart | UCLA* | Chemistry† |
| 2017 | Barry C. Barish | CalTech | Physics† |
| Michael Rosbash | CalTech* | Physiology or Medicine† | |
| 2018 | Frances Arnold | CalTech | Chemistry |
| 2020 | Andrea M. Ghez | CalTech*; UCLA | Physics† |
| Jennifer Doudna | Pomona College* | Chemistry† | |
| Charles M. Rice | CalTech* | Physiology or Medicine† | |
| 2021 | Ardem Patapoutian | UCLA*; CalTech* | Physiology or Medicine† |
| 2022 | John Clauser | CalTech* | Physics† |
* Winner had been a student/graduate/professor at this institution, but was not awarded the prize while there.
† Co-winner of the prize
Source: Nobel Prizes
